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Zoonotic Disease: A Highly Conservedbinding Region of Angiotensin-Converting Enzyme2as a Receptor for Severe Acute Respiratory Syndromecoronavirus 2 (SARS-Cov-2) between Humans and Mammals

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Zoonotic Disease: A Highly Conservedbinding Region of Angiotensin-Converting Enzyme2as a Receptor for Severe Acute Respiratory Syndromecoronavirus 2 (SARS-Cov-2) between Humans and Mammals


Takuma Hayashi | Masaki Mandai | Nobuo Yaegashi | Ikuo Konishi



Takuma Hayashi | Masaki Mandai | Nobuo Yaegashi | Ikuo Konishi "Zoonotic Disease: A Highly Conservedbinding Region of Angiotensin-Converting Enzyme2as a Receptor for Severe Acute Respiratory Syndromecoronavirus 2 (SARS-Cov-2) between Humans and Mammals" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1, December 2020, pp.1087-1092, URL: https://www.ijtsrd.com/papers/ijtsrd38191.pdf

A case of the new coronavirus severe acute respiratory syndromecoronavirus 2(SARS-CoV-2) infection transmitting from a human to a domestic cat was reported on March 27, 2020 in Belgium. Cases of SARS-CoV-2 infection being transmitted from owners to their dogs have also been reported. For the first time, however, a case of SARS-CoV-2 transmission from a human to a domestic cat has been confirmed. A tiger kept at a zoo in New York was also reportedly infected with SARS-CoV-2; it is believed that the virus was transmitted to the tiger from infected caretakers. Therefore, we examined the homology of the angiotensin-converting enzyme2 (ACE2) molecule, a receptor for the spike glycoprotein on the virionsurface of SARS-CoV-2, between humans, dogs, cats, and other mammals. We found that the binding region of theACE2 molecule with the SARS-CoV-2 spike glycoprotein has high homology between humans, dogs, cats, tigers, and other mammals. Although the transmission of human coronavirus to petsor animals is rare, SARS-CoV-2 transmission from animals or pets to humans have not yet been demonstrated. The Belgian Health Service considers zoonotic infection as a special case. However, the Belgian Health Service has suggested individuals with SARS-CoV-2 to also avoid contact with pets or other animals.

ACE2, Binding region, COVID-19, Severe acute respiratory syndrome coronavirus 2


IJTSRD38191
Volume-5 | Issue-1, December 2020
1087-1092
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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